Mutagenesis Pregabalin was not mutagenic in bacteria or in mammalian cells in vitro, was not clastogenic in mammalian devices in vitro As well as in vivo, and did not induce unscheduled DNA synthesis in mouse or rat hepatocytes.
Các đặc tính dược động học của chế độ đa liều có thể dự đoán được từ các dữ liệu của liều đơn. Vì vậy không cần thiết phải kiểm tra định kỳ nồng độ pregabalin trong huyết tương.
Pregabalin được thải trừ khỏi hệ tuần hoàn chủ yếu do bài tiết qua thận dưới dạng không chuyển hóa.
Nếu phải ngưng dùng pregabalin, cần giảm liều từ từ trong thời gian tối thiểu là one tuần.
People who are started out on therapy ought to be carefully observed for medical worsening, suicidal views, or abnormal improvements in actions.
are breastfeeding or plan to breastfeed. LYRICA passes into your breast milk. It's not necessarily known if LYRICA can harm your child. Talk with your Health care provider about The obvious way to feed your newborn if you take LYRICA. Breastfeeding will not be recommended whilst using LYRICA.
Will not push an automobile, function with devices, or do other perilous functions until finally you know the way LYRICA affects you. •
Sự an toàn và Helloệu quả của pregabalin cho trẻ em dưới twelve tuổi và thiếu niên chưa được thiết lập.
Subset evaluations of the antiseizure efficacy of LYRICA confirmed no clinically vital differences as a functionality of age, gender, or race.
Is pregabalin a managed medication? Pregabalin is actually a controlled drugs. What this means is you will discover rigorous principles regarding how It is really prescribed and dispensed to be certain it is not offered to the incorrect person or misused.
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If you have epilepsy it is vital to get pregabalin routinely. Lacking doses could bring about a seizure.
Population pharmacokinetic analyses in people taken care of with pregabalin and various concomitant prescription drugs recommend the subsequent:
You may as well check with your doctor when you are involved you have become bodily dependant on pregabalin.